A Live Attenuated H9N2 Influenza Vaccine Is Well Tolerated and Immunogenic in Healthy Adults
Identifieur interne : 001147 ( Main/Exploration ); précédent : 001146; suivant : 001148A Live Attenuated H9N2 Influenza Vaccine Is Well Tolerated and Immunogenic in Healthy Adults
Auteurs : Ruth A. Karron [États-Unis] ; Karen Callahan ; Catherine Luke ; Bhagvanji Thumar ; Josephine Mcauliffe ; Elizabeth Schappell ; Tomy Joseph ; Kathleen Coelingh [États-Unis] ; Hong Jin [États-Unis] ; George Kemble [États-Unis] ; Brian R. Murphy ; Kanta SubbaraoSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2009.
Abstract
Development of live attenuated influenza vaccines (LAIV) against avian strains with pandemic potential is an important public-health strategy. Either 1 or 2 107-TCID50 doses of H9N2 LAIV A/chicken/Hong Kong/G9/97 were administered intranasally to 50 adults in isolation; 41 participants were H9N2 seronegative, 24 of whom received 2 doses. The vaccine was well tolerated; vaccine shedding was minimal. After 2 doses, 92% of H9-seronegative participants had ⩾4-fold increases in hemagglutination-inhibition antibody, and 79% had ⩾4-fold increases in neutralizing antibody; 100% had responses detected by at least 1 assay. Although replication of the H9N2 LAIV was restricted, 2 doses were immunogenic in H9N2-seronegative adults.Trial registration ClinicalTrials.gov identifier: NCT00110279
Url:
DOI: 10.1086/596558
Affiliations:
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Karron</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Callahan, Karen" sort="Callahan, Karen" uniqKey="Callahan K" first="Karen" last="Callahan">Karen Callahan</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Luke, Catherine" sort="Luke, Catherine" uniqKey="Luke C" first="Catherine" last="Luke">Catherine Luke</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Thumar, Bhagvanji" sort="Thumar, Bhagvanji" uniqKey="Thumar B" first="Bhagvanji" last="Thumar">Bhagvanji Thumar</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Mcauliffe, Josephine" sort="Mcauliffe, Josephine" uniqKey="Mcauliffe J" first="Josephine" last="Mcauliffe">Josephine Mcauliffe</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Schappell, Elizabeth" sort="Schappell, Elizabeth" uniqKey="Schappell E" first="Elizabeth" last="Schappell">Elizabeth Schappell</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Joseph, Tomy" sort="Joseph, Tomy" uniqKey="Joseph T" first="Tomy" last="Joseph">Tomy Joseph</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Coelingh, Kathleen" sort="Coelingh, Kathleen" uniqKey="Coelingh K" first="Kathleen" last="Coelingh">Kathleen Coelingh</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>MedImmune, Gaithersburg</wicri:cityArea></affiliation></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>MedImmune, Gaithersburg</wicri:cityArea></affiliation></author><author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>MedImmune, Gaithersburg</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. 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Either 1 or 2 107-TCID50 doses of H9N2 LAIV A/chicken/Hong Kong/G9/97 were administered intranasally to 50 adults in isolation; 41 participants were H9N2 seronegative, 24 of whom received 2 doses. The vaccine was well tolerated; vaccine shedding was minimal. After 2 doses, 92% of H9-seronegative participants had ⩾4-fold increases in hemagglutination-inhibition antibody, and 79% had ⩾4-fold increases in neutralizing antibody; 100% had responses detected by at least 1 assay. 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Murphy</name><name sortKey="Schappell, Elizabeth" sort="Schappell, Elizabeth" uniqKey="Schappell E" first="Elizabeth" last="Schappell">Elizabeth Schappell</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Thumar, Bhagvanji" sort="Thumar, Bhagvanji" uniqKey="Thumar B" first="Bhagvanji" last="Thumar">Bhagvanji Thumar</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Karron, Ruth A" sort="Karron, Ruth A" uniqKey="Karron R" first="Ruth A." last="Karron">Ruth A. Karron</name></noRegion><name sortKey="Coelingh, Kathleen" sort="Coelingh, Kathleen" uniqKey="Coelingh K" first="Kathleen" last="Coelingh">Kathleen Coelingh</name><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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